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MetNet - plant pathway - phosphatidylcholine biosynthesis II
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Pathway details: phosphatidylcholine biosynthesis II

General info Interaction details Linked pathways Protein-protein interactions
  Pathway was created on Mon Jul 29, 2013.
 Contributed by aracyc:
Phosphatidylcholine is one of the major constituents of membrane phospholipids (see phospholipid biosynthesis II). The phosphatidylcholine biosynthetic pathways vary among different organisms. There are at least four alternative routes have been reported in plants. Two additional routes were reported in animals and bacteria. 1) The Kennedy pathway (phosphatidylcholine biosynthesis I) depends on choline kinase and on the availability of choline. 2) The second pathway (depicted here) depends on three consecutive N-methylation steps that are carried out on phospho-bases, phosphoethanolamine, phospho-N-methylethanolamine, and phospho-N-dimethylethanolamine. 3) The third pathway (phosphatidylcholine biosynthesis III) depends on an initial N-methylation with phospho-base phosphoethanolamine, and followed by two downstream N-methylations on phosphatidyl-bases, phosphatidyl-N-methylethanolamine and phosphatidyl-N-dimethylethanolamine. In plants, phosphatidyl-N-methylethanolamine is believed to be derived from CDP-methylethanolamine, whereas in animals, it is a direct methylation product from phosphatidylethanolamine. 4) The forth pathway (phosphatidylcholine biosynthesis IV) depends on two N-methylations with phospho-base phosphoethanolamine and phospho-N-methylethanolamine, followed by a downstream N-methylation on phosphatidyl-base phosphatidyl-N-dimethylethanolamine. Radio tracer experiments with crude cell extracts suggested such a pathway in Lemna and carrot, but not in soybean. An Arabidopsis gene (AtNMT1) was isolated through functional complementation of a yeast mutant deficient in phosphatidylcholine. Assay of the AtNMT1 recombinant enzyme indicated that it catalyzes three sequential methylations of phosphoethanolamine to form phosphocholine.
  Parts of this pathway occur in:   cytosol     nucleus     endoplasmic reticulum  

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Enzymatic reaction
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metabolite [18]
RNA [13]
polypeptide [13]
gene [13]
protein complex [6]

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