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MetNet - plant pathway - superpathway of phosphatidylcholine biosynthesis
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Pathway details: superpathway of phosphatidylcholine biosynthesis

General info Interaction details Linked pathways Protein-protein interactions
  Pathway was created on Mon Jul 29, 2013.
 Contributed by aracyc:
Supporting evidence for this pathway in Arabidopsis: This is a superpathway composed of one or more sub-pathways that may have different levels of evidence. All of its sub-pathways have been accepted for this species using SAVI v.1.0 [more info] Summary from MetaCyc: Please note: This pathway does not represent a single organism. Rather, it is a super-pathway assembled from many pathways found in a variety of organisms, whose purpose is to provide an overview of the metabolic capabilities found in nature, pertaining to the biosynthesis of phosphatidylcholine. Phosphatidylcholine is one of the major constituents of membrane phospholipids (see phospholipid biosynthesis II). The phosphatidylcholine biosynthetic pathways vary among different organisms. There are at least four alternative routes have been reported in plants. Two additional routes were reported in animals and bacteria (see pathways and ). 1) The Kennedy pathway (phosphatidylcholine biosynthesis I) depends on choline kinase and on the availability of choline. 2) The second pathway (phosphatidylcholine biosynthesis II) depends on three consecutive N-methylation steps that are carried out on phospho-bases, phosphoethanolamine, phospho-N-methylethanolamine, and phospho-N-dimethylethanolamine. 3) The third pathway (phosphatidylcholine biosynthesis III) depends on an initial N-methylation with phospho-base phosphoethanolamine, and followed by two downstream N-methylations on phosphatidyl-bases, phosphatidyl-N-methylethanolamine and phosphatidyl-N-dimethylethanolamine. In plants, phosphatidyl-N-methylethanolamine is believed to be derived from CDP-methylethanolamine, whereas in animals, it is a direct methylation product from phosphatidylethanolamine. 4) The fourth pathway (phosphatidylcholine biosynthesis IV) depends on two N-methylations with phospho-base phosphoethanolamine and phospho-N-methylethanolamine, followed by a downstream N-methylation on phosphatidyl-base phosphatidyl-N-dimethylethanolamine.
  Parts of this pathway occur in:   cytosol     nucleus     endoplasmic reticulum  

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Enzymatic reaction
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metabolite [31]
RNA [17]
polypeptide [19]
gene [17]
protein complex [8]

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