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MetNet - plant pathway - phosphatidylcholine biosynthesis IV
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Pathway details: phosphatidylcholine biosynthesis IV


General info Interaction details Linked pathways Protein-protein interactions
Notes
  Pathway was created on Mon Jul 29, 2013.
 Contributed by aracyc:
Phosphatidylcholine is one of the major constituents of membrane phospholipids (see phospholipid biosynthesis II). The phosphatidylcholine biosynthetic pathways vary among different organisms. There are at least four alternative routes have been reported in plants. Two additional routes were reported in animals and bacteria. 1) The Kennedy pathway (phosphatidylcholine biosynthesis I) depends on choline kinase and on the availability of choline. 2) The second pathway (phosphatidylcholine biosynthesis II) depends on three consecutive N-methylation steps that are carried out on phospho-bases, phosphoethanolamine, phospho-N-methylethanolamine, and phospho-N-dimethylethanolamine. 3) The third pathway (phosphatidylcholine biosynthesis IV) depends on an initial N-methylation with phospho-base phosphoethanolamine, and followed by two downstream N-methylations on phosphatidyl-bases, phosphatidyl-N-methylethanolamine and phosphatidyl-N-dimethylethanolamine. In plants, phosphatidyl-N-methylethanolamine is believed to be derived from CDP-methylethanolamine, whereas in animals, it is a direct methylation product from phosphatidylethanolamine. 4) The forth pathway (depicted here) depends on two N-methylations with phospho-base phosphoethanolamine and phospho-N-methylethanolamine, followed by a downstream N-methylation on phosphatidyl-base phosphatidyl-N-dimethylethanolamine. Radio tracer experiments with crude cell extracts suggested such a pathway in carrot and in olive.
  Parts of this pathway occur in:   cytosol     nucleus  


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