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Pathway details: pentose phosphate pathway (non-oxidative branch)

General info Interaction details Linked pathways Protein-protein interactions
  Pathway was created on Mon Jul 29, 2013.
 Contributed by aracyc:
General Information: The pentose phosphate pathway is an alternative way of oxidizing glucose. This oxidation is coupled with NADPH synthesis. The pathway has two primary reaction sequences: the pentose phosphate pathway (oxidative branch) and the pentose phosphate pathway (non-oxidative branch). In the former, β-D-glucose-6-phosphate is oxidized to D-ribulose-5-phosphate; this step is the source of reducing equivalents for biosynthesis reactions in the shape of NADPH. The subsequent non-oxidative portion (the branch represented here) represents a series of transaldolase and transketolase reactions, in which D-ribulose-5-phosphate is converted into D-fructose-6-phosphate and D-glyceraldehyde-3-phosphate. As a result this pathway is a source of reducing power and is also important for the conversion of hexoses to pentoses |CITS:[Zubay83]|. This pathway is usually understood to be cytosolic. However, it was shown in spinach that the complete set of pentose phosphate pathway enzymes could be found in the chloroplasts of leaf cells, whereas only enzymes covering the first two steps of the pathway could be found in the cytosol . Additional information on the pathway and its enzymatic regulation can be found in |CITS:[BROWNLEADER97]|.
  Parts of this pathway occur in:   plastid stroma     cytosol     nucleus     plastid   multiple locations  

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Enzymatic reaction
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RNA [14]
polypeptide [16]
gene [14]
metabolite [10]
protein complex [8]

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