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Pathway details: proline biosynthesis I

General info Interaction details Linked pathways Protein-protein interactions
  Pathway was created on Mon Jul 29, 2013.
 Contributed by aracyc:
Supporting evidence for this pathway in Arabidopsis: Enzyme(s) that catalyzes one or more of the key reactions in this pathway were predicted in Arabidopsis. [more info] Summary from MetaCyc: This universal pathway is found in organisms ranging from bacteria to , although the input to the pathway, L-glutamate, is formed by different means in different organisms. For example, in mammals, L-glutamate is formed in the mitochondrial matrix by an NAD(P)+-dependent glutamate dehydrogenase (EC and transported to the cytoplasm, where the rest of the reactions occur, while in bacteria glutamate is formed by a NADP+-dependent enzyme (EC The first two enzymes, and , form the . Complex formation is necessary for the activity of the first enzyme, but not for the second. The product of the complex, L-glutamate γ-semialdehyde, rearranges spontaneously to form pyrroline 5-carboxylate, which is converted to L-proline in a single step, catalyzed by .
  Parts of this pathway occur in: multiple locations     cytosol     nucleus  

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