Warning: session_start() [function.session-start]: open(C:\Windows\Temp\\sess_0uurngtbm9ofm62c05m8p7r712, O_RDWR) failed: Invalid argument (22) in D:\inetpub\wwwroot\include\lib_auth.php on line 5

Warning: Cannot modify header information - headers already sent by (output started at D:\inetpub\wwwroot\include\ui_pathway.php:63) in D:\inetpub\wwwroot\include\ui_pathway.php on line 83

Warning: Cannot modify header information - headers already sent by (output started at D:\inetpub\wwwroot\include\ui_pathway.php:63) in D:\inetpub\wwwroot\include\data_organism.php on line 119
MetNet - plant pathway - allantoin degradation to glyoxylate I
  export functions:            

Pathway details: allantoin degradation to glyoxylate I


General info Interaction details Linked pathways Protein-protein interactions
Notes
  Pathway was created on Mon Jul 29, 2013.
 Contributed by aracyc:
Supporting evidence for this pathway in Arabidopsis: This is a superpathway composed of one or more sub-pathways that may have different levels of evidence. All of its sub-pathways have been accepted for this species using SAVI v.1.0 [more info] Summary from MetaCyc: General Background allantoin is a common product of purine degradation. Allantoin is rich in nitrogen, and many organisms are able to degrade and recycle it. Some bacteria, including , and , do so under aerobic conditions, while others such as , and do so only anaerobically. Allantoin degradation is not limited to bacteria. Ureide-transporting plants convert fixed nitrogen in their roots to allantoin and allantoate, which are then transported to upper parts of the plant, where they are degraded to release the nitrogen. In addition, some fungi and animals also degrade allantoin. The first step of the pathway, catalyzed by , comprises the hydrolysis of the internal amide bond of S-allantoin, forming allantoate . This enzyme turned out to be common to all organisms that can degrade allantoin, and is the first step in all allantoin degradation pathways. allantoate is converted to (S)-ureidoglycolate via one of two routes. In the first route the nitrogen is liberated in a single step in the form of urea ("EC 3.5.3.4"), while in the other route it is liberated in the form of ammonia in two steps, via the intermediate (starting with "EC 3.5.3.9"). The next step in the pathway is the conversion of (S)-ureidoglycolate to glyoxylate. Similarly, this conversion can proceed with the liberation of either urea ("EC 4.3.2.3") or ammonia ("EC 3.5.3.19"). Several combinations of these routes have been documented. Some organisms possess pathways that produce solely urea (see ), some produce only ammonia (see allantoin degradation to glyoxylate II), and some produce both (see ). In addition, some anaerobic organisms can degrade allantoin to instead of glyoxylate (see ). About This Pathway Several organisms, including and some bacteria, can utilize S-allantoin as a sole nitrogen source by degrading it to urea, CO2 and glyoxylate. In this pathway, allantoate is hydrolyzed to (S)-ureidoglycolate by , and (S)-ureidoglycolate is converted to glyoxylate and urea by . glyoxylate then enters general metabolism, where it is converted by the successive action of three enzymes to 3-phosphoglycerate (see ). The nitrogen, which is liberated in the form of two urea molecules, may be subsequently converted to ammonia by or (see ) . For more information about the yeast pathway, please see .
  Parts of this pathway occur in:   cytosol     nucleus  


interactions
View raw
Browse interactions [16]: By type By location All interactions
Type
Enzymatic reaction
Transcription
Translation
Composition-OR
Catalysis
Participating entities and compounds
Linked pathways
Browse entities [20]: By type Sources & sinks All entities


Copyright © 2006-2016 Wurtele lab. Copyright refers to the integration and online application, not the data from the various sources.

 

Number of queries executed: 10

Warning: Unknown: open(C:\Windows\Temp\\sess_0uurngtbm9ofm62c05m8p7r712, O_RDWR) failed: Invalid argument (22) in Unknown on line 0

Warning: Unknown: Failed to write session data (files). Please verify that the current setting of session.save_path is correct (C:\Windows\Temp\) in Unknown on line 0