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MetNet - plant pathway - aliphatic glucosinolate biosynthesis, side chain elongation cycle
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Pathway details: aliphatic glucosinolate biosynthesis, side chain elongation cycle


General info Interaction details Linked pathways Protein-protein interactions
Notes
  Pathway was created on Mon Jul 29, 2013.
 Contributed by aracyc:
General Background The biosynthesis of aliphatic glucosinolates is divided into three major stages, first the chain elongation of amino acids such as methionine (this pathway) and phenylalanine, followed by the core biosynthesis of the glucosinolates (compare glucosinolate biosynthesis from homomethionine) and finally secondary modifications of the glucosinolates . The structural diversity of glucosinolates results from different precursor amino acids, varying length of the side chain and different patterns of secondary oxidation and esterification |CITS: [TOKUHISA04]|. Over 120 different glucosinolates have been described so far in plants . Glucosinolates belong to one of the largest group of secondary metabolites found in the model plant Arabidopsis thaliana , where 39 glucosinolates have been identified in 34 different ecotypes indicating the plasticity of glucosinolate biosynthesis. A significant part of that diversity of aliphatic glucosinolates in Arabidopsis is based on varying side chain length . About This Pathway The reaction sequence that is characteristic for the side chain elongation of methionine comprises three steps. Those reactions form a cycle which is repeatedly run through for the production of the C3 to C8 glucosinolates (the number of C refers to the number of methylene groups in the side chain) found in Arabidopsis . The first step is the condensation of acetyl-CoA with the deaminated 2-oxo-derivative of methionine, followed by the isomerization of the generated 2-malate derivative to form a 3-malate derivative which finally undergoes oxidative decarboxylation yielding a 2-oxo acid that is elongated by one more methylene group and can either reenter the cycle or proceed to the core biosynthetic steps . This side chain elongation cycle very much resembles the reaction sequence being found in leucine biosynthesis. Therefore it was not surprising that enzymes of leucine biosynthesis also function in methionine chain elongation leading to glucosinolate biosynthesis, and vise versa ,,.
  Parts of this pathway occur in:   cytosol     nucleus     plastid  


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metabolite [20]
protein complex [9]
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gene [13]


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