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MetNet - plant pathway - 4-hydroxybenzoate biosynthesis I (animals)
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Pathway details: 4-hydroxybenzoate biosynthesis I (animals)


General info Interaction details Linked pathways Protein-protein interactions
Notes
  Pathway was created on Mon Jul 29, 2013.
 Contributed by aracyc:
Supporting evidence for this pathway in Arabidopsis: Enzyme(s) that catalyzes one or more of the key reactions in this pathway were predicted in Arabidopsis. [more info] Summary from MetaCyc: Higher eukaryotes produce p-hydroxybenzoate from L-tyrosine, as described in this pathway. In addition, the pathway is found in some lower eukaryotes even though they possess the shikimate pathway (see ), allowing them to synthesize p-hydroxybenzoate directly from chorismate (see ). This important pathway has received surprisingly little attention, and has not been characterized very well. A pathway for the conversion of L-tyrosine to p-hydroxybenzoate was proposed already in 1960, based on urinary excretion studies on animals administered with various phenolic acids and the incorporation of radiolabeled phenolic acids into ubiquinone by rat liver and yeast |CITS: [Booth60]|. Based on those results, it was suggested that L-tyrosine is converted to p-hydroxyphenylpyruvate, which is then modified to 4-hydroxyphenyllactate and 4-coumarate |CITS: [Booth60]|. These results were confirmed by additional work performed with rat . The later part of the pathway, starting with 4-coumarate, has not been studied much in animals. In plants it has been shown that 4-coumarate is converted to p-hydroxybenzoate either directly (see ) or via CoA derivatives such as coumaroyl-CoA and (see ).
  Parts of this pathway occur in:   cytosol     nucleus     endoplasmic reticulum     peroxisome  


interactions
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Enzymatic reaction
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Type
metabolite [17]
protein complex [3]
gene [12]
RNA [12]
polypeptide [20]


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