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MetNet - plant pathway - 1D-<i>myo</i>-inositol hexakisphosphate biosynthesis V (from Ins(1,3,4)P3)
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Pathway details: 1D-myo-inositol hexakisphosphate biosynthesis V (from Ins(1,3,4)P3)

General info Interaction details Linked pathways Protein-protein interactions
  Pathway was created on Mon Jul 29, 2013.
 Contributed by aracyc:
Supporting evidence for this pathway in Arabidopsis: This pathway is on the list of Accept-If-Predicted Pathways, which includes pathways that are present widely throughout the plant kingdom. [more info] Summary from MetaCyc: General Background phytate (phytate, phytic acid) is one of the most prevalent forms of phosphorylated inositols in the eukaryotic cell, with a total concentration of 15-100 μM . It's cellular distribution is not completely known - some of it is soluble, some is "wall-papered" around membranes, while some is bound to proteins . In plant seeds, large amount of phytate are complexed with cations and deposited as globular inclusions in membrane-bound storage bodies . The compound has been proposed to have a number of signaling roles, including regulation of insulin exocytosis , regulation of nuclear mRNA export , binding of the clathrin assembly proteins AP2 and AP3 , inhibition of clathrin cage assembly , and inhibition of serine and threonine protein phosphatases that are thought to regulate L-type Ca2+ channels . About This Pathway In plant cells phytate serves as a storage form of myo-inositol, phosphate and mineral nutrients for utilization during seed germination and seedling growth. It is deposited within single-membrane storage organelles referred to as protein bodies and is usually present as mixed complexes with different cations, including K+, Mg2+, Ca2+, Fe2+, and Zn2+, known as phytin . Although phytin only makes up about 1% of the seed weight, it may contain up to 80% of the total seed phosphorus . Phytate is also present in other plant tissues and organs such as pollen, roots, tuber and turions in smaller quantities . One phytate biosynthetic pathway found in plants proceeds from D-myo-inositol (1,4,5)-trisphosphate (produced by phospholipase C) as described in by a series of successive phosphorylations carried out by only two enzymes. A second, indirect pathway, has been suggested to occur via D-myo-inositol (1,3,4)-trisphosphate. The pathway is indirect because D-myo-inositol (1,3,4)-trisphosphate itself is produced from D-myo-inositol (1,4,5)-trisphosphate (see ). However, once formed, D-myo-inositol (1,3,4)-trisphosphate can be phosphorylated by (), an enzyme that does not recognize D-myo-inositol (1,4,5)-trisphosphate as substrate . The products of are then phosphorylated further by the same enzymes used in .
  Parts of this pathway occur in:   cytosol     nucleus  

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Enzymatic reaction
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metabolite [13]
gene [17]
RNA [17]
polypeptide [17]
protein complex [5]

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