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MetNet - plant pathway - gluconeogenesis I
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Pathway details: gluconeogenesis I


General info Interaction details Linked pathways Protein-protein interactions
Notes
  Pathway was created on Mon Jul 29, 2013.
 Contributed by junyoni:
Gluconeogenesis is the generation of glucose from non-sugar carbon substrates such as pyruvate, lactate, glycerol, and glucogenic amino acids (primarily L-alanine and L-glutamine). The process is essentially the reversal of the glycolysis I (plastidic) pathway. However, two glycolytic enzymes catalyze irreversible reactions. In order to enable the pathway to flow in the direction of glucose production, these reactions are catalyzed by other enzymes ( and ) in the opposite direction. The pathway is particularly important in animals, as the production of glucose from other metabolites is necessary for use as a fuel source by the brain, testes, erythrocytes and kidney medulla, all of which can use only glucose as the energy source. Gluconeogenesis in animals is perfomed mostly in the liver. The pathway is carried by cytoplasmic enzymes to the level of β-D-glucose-6-phosphate. Since free glucose tends to freely diffuse out of the cell, actual glucose formation is carried out in the lumen of the endoplasmic reticulum by . Glucose is then shuttled into the cytosol by glucose transporters. The main souces of carbon for gluconeogenesis in animals is lactate, formed in skeletal muscle cells during anaerobic glycolysis and carried to the liver in the blood stream. The conversion of glucose into lactate by glycolysis and back to glucose by gluconeogenesis is referred to as the Cori Cycle .
  Parts of this pathway occur in:   cytosol     plastid stroma     plastid     nucleus     mitochondrion     apoplast     peroxisome   multiple locations  


interactions
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Browse interactions [196]: By type By location All interactions
Type
Enzymatic reaction
Translation
Transcription
Catalysis
Composition-OR
Composition-AND
Participating entities and compounds
Linked pathways
Browse entities [293]: By type Sources & sinks All entities

Type
metabolite [37]
gene [77]
RNA [77]
polypeptide [82]
protein complex [20]


Copyright © 2006-2016 Wurtele lab. Copyright refers to the integration and online application, not the data from the various sources.

 

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