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MetNet - plant pathway - leucine degradation
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Pathway details: leucine degradation


General info Interaction details Linked pathways Protein-protein interactions
Notes
  Pathway was created on Tue Jun 14, 2011.
 Contributed by wangyi:
While Saccharomyces cerevisiae can use most amino acids as their sole nitrogen source, they can only use a few amino acids as a carbon source to support growth |CITS:[Large86][Cooper82]|. This is in contrast to most eukaryotes and some fungi, which can metabolize amino acids completely, utilizing them as sole sources of carbon and nitrogen |CITS:[Stryer88][Large 86]|. S. cerevisiae degrade the branched-chain amino acids (leucine, iso-leucine, and valine) and the aromatic amino acids (tryptophan, phenylalanine, and tyrosine) via the Ehrlich pathway |CITS:[Sentheshanmuganathan60]. This pathway is comprised of the following steps: 1) deamination of the amino acid to the corresponding alpha-keto acid; 2) decarboxylation of the resulting alpha-keto acid to the respective aldehyde; and, 3) reduction of the aldehyde to form the corresponding long chain or complex alcohol, known as a fusel alcohol or fusel oil [Large 86]|. Fusel alcohols are important flavor and aroma compounds in yeast-fermented food products and beverages (as reported in . Each of the three steps in branched-chain amino acid degradation can be catalyzed by more than one isozyme; which enzyme is used appears to depend on the amino acid, the carbon source and the stage of growth of the culture . In leucine degradation, Thi3p is believed to be the major decarboxylase .
  Parts of this pathway occur in:   cytosol     nucleus  


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